Topical glucocorticoids modulate the lesion interface after cerebral cortical stab wounds in adult rats
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چکیده
منابع مشابه
Topical glucocorticoids modulate the lesion interface after cerebral cortical stab wounds in adult rats.
A lesion interface, consisting of a glia limitans lined by a laminin-rich basal lamina and leptomeningeal cells, forms within 2-3 weeks after penetrating wounds to the adult mammalian central nervous system (CNS). This interface prevents the growth of axons across the lesion. We have examined the effects of topically applied steroids on the formation of such an interface after stab wounds to th...
متن کاملDifferent glial reactions to hippocampal stab wounds in young adult and aged rats.
Brain injury induces reactive gliosis. To examine the activation of glial cells after brain injury in young versus aged rats, we used a brain stab-wound model and examined the expression of cells positive for ED1 (ED1(+)) and glial fibrillary acidic protein (GFAP(+)) in the hippocampus in young-mature (3 months) and aged (25 months) Wistar rats at various times following hippocampal stab injury...
متن کاملStab wounds of the brain.
Unlike the penetrating injuries to the brain caused by missiles, injuries by stabbing are largely restricted to the wound tract. Early recognition, debridement and judicious antibiotic therapy can limit or prevent complications in the management of stab wounds. Among the common sequelae of stab wounds of the brain are pneumocephalus, meningitis, intracerebral hemorrhage and direct blood vessel ...
متن کاملA study of stab wounds.
A study was made of patients with stab wounds who attended the Accident and Emergency Department of Glasgow Royal Infirmary during 1978 and 1983. There were 318 patients. The majority, 304 (96%), were males. A total of 87 (27%) were teenagers. The most common sites of the wounds were the chest (143 patients) and the abdomen (113 patients). The features of the patients and their wounds are compa...
متن کاملCortical neurogenesis in adult rats after transient middle cerebral artery occlusion.
BACKGROUND AND PURPOSE This study explored the possible occurrence of newly generated nerve cells in the ischemic cortex of adult rats after middle cerebral artery occlusion and reperfusion. METHODS Nine- to 10-week-old male Wistar rats were subjected to 2 hours of middle cerebral artery occlusion by the monofilament method. Rats received repeated intraperitoneal injections of the cell prolif...
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ژورنال
عنوان ژورنال: Glia
سال: 1996
ISSN: 0894-1491,1098-1136
DOI: 10.1002/(sici)1098-1136(199612)18:4<306::aid-glia5>3.0.co;2-v